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FLASH GENE
Symbol ZNRF2 contributors: mct - updated : 16-05-2018
HGNC name zinc and ring finger 2
HGNC id 22316
Location 7p15.1      Physical location : 30.323.922 - 30.407.307
Synonym name
  • E3 ubiquitin-protein ligase ZNRF2
  • RING finger protein 202
  • protein Ells2
  • Synonym symbol(s) RNF202
    EC.number 6.3.2.-/ 2.3.2.27
    DNA
    TYPE functioning gene
    STRUCTURE 83.39 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 3485 - 242 - 2003 14561866
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Nervous    
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    one RING-type C3HC4 zinc finger
    HOMOLOGY
    interspecies homolog to rattus LOC362367
    Homologene
    FAMILY ZNRF E3 ubiquitin ligases family
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • ubiquitin-protein ligase activity
  • play a role in the establishment and maintenance of neuronal transmission
  • ZNRF2, and its sister protein ZNRF1 regulate the Na(+)/K(+) pump (Na(+)/K(+)ATPase)
  • ZNRF1 and ZNRF2 are new players in regulation of the ubiquitous Na(+)/K(+)ATPase that is tuned to changing demands in many physiological contexts
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    Zn2+
    protein
  • ZNRF2, interact with UBE2N through its RING finger domain
  • ZNRF1 and ZNRF2 can ubiquitylate the cytoplasmic loop encompassing the nucleotide-binding and phosphorylation regions of the ATP1A1 subunit
  • ZNRF2 is a component of the amino acid sensing machinery that acts upstream of Rag-GTPases and the V-ATPase to activate MTOR
  • ZNRF2 appeared to augment MTOR and its downstream targets CCND1 and CDK in non-small cell lung cancer cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS