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FLASH GENE
Symbol CASC4 contributors: - updated : 13-12-2005
HGNC name cancer susceptibility candidate 4
HGNC id 24892
Location 15q15.3      Physical location : 44.580.928 - 44.707.958
Synonym symbol(s) H63, MGC74708
DNA
TYPE functioning gene
STRUCTURE 127.00 kb     14 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing 4011 - 436 - Oh
nine exons encoding the longer transcript and the longer isoform a
- splicing 3843 - 380 - Oh
eight exons, lacking an in-frame segment, resulting in a shorter isoform b missing an internal segment compared to isoform a
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel    
Digestivemouthtongue   
Lymphoid/Immunelymph node    
 spleen    
Reproductivemale systemtestis   
Respiratoryrespiratory tractlarynx   
Urinarybladder   predominantly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to chimpanzee LOC467670
ortholog to dog LOC478283
ortholog to murine Casc4
Homologene
FAMILY
CATEGORY protooncogene
SUBCELLULAR LOCALIZATION
basic FUNCTION unknown
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
signaling
a component
INTERACTION
DNA
RNA
small molecule
protein
cell & other
REGULATION
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
associated with ERBB2 proto-oncogene overexpression
Susceptibility to breast and ovarian cancers
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS