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FLASH GENE
Symbol METTL11A contributors: mct - updated : 02-05-2018
HGNC name methyltransferase like 11A
HGNC id 23373
Location 9q34.11      Physical location : 132.388.434 - 132.397.879
Synonym name
  • N-terminal RCC1 methyltransferase
  • X-Pro-Lys N-terminal protein methyltransferase 1A
  • alpha N-terminal protein methyltransferase 1A
  • chromosome 9 open reading frame 32
  • Synonym symbol(s) AD-003, C9orf32, NRMT, NTM1A
    EC.number 2.1.1.-
    DNA
    TYPE functioning gene
    STRUCTURE 9.45 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1007 25 223 - 2010 20668449
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
    Skin/Tegumentskin    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a Rossman-like alpha/beta fold
  • lacks a SET domain
  • HOMOLOGY
    Homologene
    FAMILY
  • methyltransferase superfamily
  • methyltransferase 11 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • acting as a S-adenosylmethionine-dependent methyltransferase
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • predominant alpha-N-methyltransferase for RCC1
  • is a major enzyme required for the CENPB methylation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    silencing METTL11A reduces RCC1 association with chromatin, and increases frequency of mitotic defects
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS