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FLASH GENE

Symbol

E2F7

contributors: mct - updated : 15-03-2022

HGNC name	E2F transcription factor 7
HGNC id	23820

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	12q21.2      Physical location : 77.415.026 - 77.459.360
Synonym symbol(s)	FLJ12981

DNA

TYPE	functioning gene
STRUCTURE	44.33 kb     13 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_203394 13 - 5725 NP_976328 - 911 - 2004 15133492

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive female system uterus cervix     Respiratory respiratory tract larynx

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

two DNA-binding domains (DBDs)

HOMOLOGY

Homologene

FAMILY

E2F family of transcription factors

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
	intracellular,nucleus,chromatin/chromosome
	intracellular,nucleus,nucleolus
text	localises to the perinucleolar region (PMID;

basic FUNCTION	playing an essential role in the regulation of cell cycle progression
	regulating the expression of genes involved in cell cycle, DNA replication, DNA repair, and mitosis
	E2F7 and E2F8 contain two DNA-binding domains (DBDs) and act as repressors
	synergistic functions of E2F7 and E2F8 are critical to suppress stress-induced skin cancer
	E2F7 is a key player in DNA damage-dependent transcriptional regulation of cell-cycle genes
	is an atypical E2F family member that acts as a transcriptional repressor of E2F target genes, and thereby contributes to cell cycle arrest
	E2F7 and E2F8 act as tumor suppressors via transcriptional repression of genes involved in S-phase entry and progression

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA	binds to the E2F DNA binding consensus site independently of DP co-factors

RNA

small molecule

protein	unique repressor of a subset of E2F target genes whose products are required for cell cycle progression
	TP53-dependent transcriptional up-regulation of its target, E2F7, leads to repression of relevant gene expression
	E2F7 and E2F8 promote angiogenesis through transcriptional activation of VEGFA in cooperation with HIF1A
	E2F7 restricts homologous recombination through the transcriptional repression of RAD51
	CCNF-dependent degradation of E2F7 is critical for DNA repair and G2-phase progression
	mechanistically, SAPCD2 could directly bind to cytoplasmic E2F7 but not E2F1, alter the subcellular distribution of E2F7 and regulate E2F activity

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   predicts poor prognosis in human patients with gliomas

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	might act as an independent prognostic factor of gliomas
Therapy target
	System Type Disorder Pubmed cancer brain glioma/neuroblstoma might constitute a potential therapeutic target for gliomas

ANIMAL & CELL MODELS