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FLASH GENE
Symbol TRAF3IP3 contributors: mct/npt - updated : 29-01-2010
HGNC name TRAF3 interacting protein 3
HGNC id 30766
Location 1q32.2      Physical location : 209.929.393 - 209.955.666
Synonym name
  • TRAF3-interacting Jun N-terminal kinase (JNK)-activating modulator
  • TRAF3-interacting JNK-activating modulator
  • Synonym symbol(s) DJ434O14.3, FLJ44151, T3JAM, MGC163289, MGC117354
    DNA
    TYPE functioning gene
    STRUCTURE 26.14 kb     17 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 2058 - 531 - Ma (2007)
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   highly
     thymus   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a coiled-coil domain homologous to the myosin tail heptad repeat
  • ezrin radixin moesin (ERM) family domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    basic FUNCTION
  • may function as an adapter molecule that specifically regulates TRAF3-mediated JNK activation
  • stimulating cell growth by modulating the c-Jun N-terminal kinase (JNK) pathway (Ma 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein associating specifically with TRAF3
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS