basic FUNCTION
| inositol phosphate kinase with a broad substrate specificity |
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having a preference for inositol-1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol 1,3,4,6-tetrakisphosphate |
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may regulate the level of Ins(1,4,5,6)P4 and have an effect on chloride channel regulation |
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the most catalytically diverse member of this family with critical roles in nuclear functions including mRNA export, transcriptional regulation, and chromatin remodeling |
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regulates glucose signaling to AMPK in a pathway whereby glucose activates phosphorylation of IPMK at tyrosine 174 enabling the enzyme to bind to AMPK and regulate its activation |
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role for the hypothalamic IPMK signaling in the control of AMPK and central energy homeostasis |
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multifunctional protein in cellular signal transduction, namely, a multispecific inositol phosphate kinase, phosphatidylinositol 3-kinase, and a scaffold within the MTOR-raptor complex |
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is a versatile player in insulin-, nutrient-, and energy-mediated metabolism signaling networks |
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acts potentially as a transcriptional coactivator for TP53 and it is an integral part of the TP53 transcriptional complex facilitating cell death |