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FLASH GENE
Symbol TMED2 contributors: mct - updated : 12-09-2015
HGNC name transmembrane emp24 domain trafficking protein 2
HGNC id 16996
Location 12q24.31      Physical location : 124.069.075 - 124.082.681
Synonym name
  • coated vesicle membrane protein
  • membrane protein p24A
  • Synonym symbol(s) P24A, RNP24, FLJ21323
    DNA
    TYPE functioning gene
    STRUCTURE 13.62 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 2126 22 201 - 2010 20361938
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  predominantly
     liver   moderately
     pancreas exocrine   moderately
    Reproductivefemale systemplacenta    Homo sapiens
     female systemovary  moderately
     female systembreastmammary gland moderately
     male systemprostate  moderately
    Skin/Tegumentskin   moderately
    Urinarybladder   highly
    Visualeye   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    Text expressed in syncytiotrophoblast, cytotrophoblast, and stromal cells
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a GOLD domain
  • HOMOLOGY
    interspecies ortholog to rattus Rnp24
    Homologene
    FAMILY
  • EMP24/GP25L family
  • CATEGORY receptor , transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,microsome
    text
  • type I membrane protein
  • Golgi-derived coatomer-coated vesicles
  • crucial constituent of the Golgi apparatus, associates with F2RL1 at the Golgi apparatus
  • basic FUNCTION
  • could have a role in the budding of coatomer-coated and other species of coated vesicles
  • could bind cargo molecules to collect them into budding vesicles
  • inhibiting the GTPase-activating activity of ARFGAP1
  • involved in vesicular targeting
  • cargo receptor facilitating calcium sensing receptor maturation and stabilization in the early secretory pathway
  • TMED2, TMED10 are specific cargo receptors of GPCRs and differentially control GPCR trafficking in the biosynthetic pathway, and thereby, TMED2 and TMED10 regulate GPCR signaling in astrocytes
  • required for transport of proteins between the endoplasmic reticulum and the Golgi
  • may play a role during placental development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text
  • intracellular protein transport
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ARFGAP1
  • F2RL1 and TMED2 interaction occurs between the N-terminal region of TMED2 p24A-GL (GOLD domain with a small linker) and the second extracellular loop of F2RL1, and after receptor activation, F2RL1 dissociates from TMED2
  • regulator of signal-dependent trafficking that regulates the life cycle of F2RL1
  • interactors of GCGR, LDLR and TMED2, significantly enhanced glucagon-stimulated glucose production, while YWHAB inhibited glucose production
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS