basic FUNCTION
| inhibiting transcription factors of the basic helix loop helix family |
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proper expression of ID2 is important to achieving a fine balance between growth and differentiation during chondrogenesis |
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plays a dual role in skin tumorigenesis by suppressing tumor development through the establishment of epidermal gammadelta T cell-mediated skin immunosurveillance and by promoting tumor cell proliferation via the control of the cyclin D1 protein level |
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play important roles in controlling cell fate determination, differentiation, and proliferation of various cell |
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acts as a negative regulator of the differentiation of immature B cells occurring in the spleen, and MXD3 negatively regulates B cell differentiation in the spleen by inducing ID2 expression |
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promotes tumor cell migration and invasion through transcriptional repression of semaphorin 3F |
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major differentiation factors of the NK-cell lineage, including HOXA9, HOXA10 and ID2, were (de)regulated via polycomb repressor complex 2 (PRC2) which therefore contributes to T-cell leukemogenesis |
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play an essential role in the regulation of breast epithelial cell differentiation and proliferation |
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rhythmically expressed HLH transcriptional repressor |
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contributes to both input and output components of the clock and that this may be via interaction with the bHLH clock proteins CLOCK and ARNTL1 |
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could potentially regulate aspects of both clock input and output through a time-of-day specific interaction with CLOCK and ARNTL1 |
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acts as an oncogene and elevated levels of ID2 have been reported in several malignancies |
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ID2/TCF3 axis orchestrates T cell differentiation through the induction or repression of downstream transcription factors essential for effector and memory T cell differentiation |
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morphologically, ID2/ID3 proteins seem to be involved in the granulopoietic maturation |
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ID2 and ID3 enforce follicular regulatory T (TFR) cell- checkpoints and control the maintenance and homing of Treg cells |