basic FUNCTION
| promoting proliferation of cells |
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regulation of GTPase activity |
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Arf GTPase-activating protein implicated in the pathogenesis of hepatocellular carcinoma, and that may regulate cell migration associated with the invasion of normal tissue by cancer cells |
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having functions nonredundant with ASAP1 to control cell movement and may have a role in cancer cell invasion |
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present in cell structures required for cell migration and invasion, such as focal adhesions, invadopodias, and podosomes, and are involved in endocytosis and cytoskeletal remodeling 0) |
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involvement in carcinogenesis and metastasis highlights the importance of the presented structure in general and the Ca2+-binding pocket in particular as it may give clues for designing inhibitors for therapeutic applications |
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novel function for ASAP3 in the regulation of cell migration through controlling ITGB1 dynamics |
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important regulator in cancer cell migration/invasion and actin-based cytoskeletal remodeling |