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FLASH GENE
Symbol SSR3 contributors: mct - updated : 02-05-2017
HGNC name signal sequence receptor, gamma (translocon-associated protein gamma)
HGNC id 11325
Location 3q25.31      Physical location : 156.257.928 - 156.272.973
Synonym name
  • translocon-associated protein subunit gamma
  • Synonym symbol(s) TRAPG, SSR gamma
    DNA
    TYPE functioning gene
    STRUCTURE 15.65 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 4331 - 185 - 2013 23660295
    5 - 4370 - 198 - 2013 23660295
    5 - 4196 - 133 - 2013 23660295
    5 - 4220 - 133 - 2013 23660295
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
    Digestiveintestinesmall intestine  highly
     liver   moderately
    Lymphoid/Immunespleen   moderately
    Nervousbrain   moderately
    Reproductivefemale systemuterus  moderately
     male systemprostate  highly
    Respiratoryrespiratory tractlarynx  moderately
    Skin/Tegumentskin   moderately
    Urinarybladder   highly
     kidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Connectivebone   
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four predicted transmembrane domains
  • mono polymer heteromer , tetramer
    HOMOLOGY
    interspecies ortholog to murine Ssr3
    Homologene
    FAMILY
    CATEGORY regulatory , receptor membrane
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,cytosolic,microsome
    text
  • integral to endoplasmic reticulum membrane
  • translocon complex
  • basic FUNCTION
  • binding calcium to the ER membrane
  • regulating the retention of ER resident proteins
  • appears to be likely required for vascular network formation in placental development
  • CELLULAR PROCESS protein, post translation, targeting
    PHYSIOLOGICAL PROCESS
    text
  • cotranslational protein-membrane targeting
  • protein translocation across the ER membrane
  • PATHWAY
    metabolism
    signaling
    a component
  • heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
  • interaction between NR4A1 and SSR3 (ligand-binding domain of NR4A1 was required for SSR3 binding, and the C terminus of SSR3 was responsible for its interaction with NR4A1)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification    
    in esophageal squamous cell carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS