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FLASH GENE
Symbol CLMP contributors: mct - updated : 29-05-2019
HGNC name CXADR like membrane protein
HGNC id 24039
Corresponding disease
CSBS congenital short bowel syndrome
Location 11q24.1      Physical location : -
Genatlas name adipocyte-specific adhesion molecule
Synonym name
  • CAR-like membrane protein
  • adipocyte adhesion molecule
  • Synonym symbol(s) ASAM, FLJ22415, UNQ318, SLLL318, ACAM
    DNA
    TYPE functioning gene
    STRUCTURE 123.30 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2955 - 373 - 2016 27720179
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel   highly
    Digestiveintestinesmall intestine  highly
    Hearing/Equilibriumearinnercochlea highly
    Reproductivefemale systemuteruscervix moderately
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Connectiveadipose  highly
    Connectivebone   
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a signal peptide
  • V-type (variable) domain
  • C2-type (constant) Ig domain
  • a single transmembrane segment
  • a cytoplasmic tail
  • extracellular immunoglobulin (Ig)-like domain(s)
  • cytoplasmic juxtamembrane domain
  • C-terminal PZD-binding domain
  • HOMOLOGY
    Homologene
    FAMILY
  • CTX gene family
  • CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,tight
        intracellular
    intracellular,cytoplasm
    text
  • type I transmembrane protein
  • co-localized with the tight junction markers ZO-1 and occludin
  • basic FUNCTION
  • may be the critical adhesion molecule in adipocyte differentiation and development of obesity
  • acting as a receptor for group b coxsackieviruses and subgroup c of adenoviruses
  • probably involved in transepithelial migration of polymorphonuclear leukocytes (pmn) through adhesive interactions with AMICA1 located in the plasma membrane of pmn
  • plays a role in intestinal development, but does not play a key role in cellular processes involved in intestinal epithelial development
  • is a novel cell-cell adhesion molecule
  • may be important role in cell adhesion events during ovulation and luteal formation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the epithelial apical junction complex that is essential for the tight junction integrity
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TNF-mediated mRNA degradation of the CLMP gene is controlled by TTP (tristetraprolin) through the JNK signalling cascade
  • absence of CLMP caused a severe reduction of GJA1, GJC1 in smooth muscle cells of the intestine and of GJA1 in the ureter
  • cell & other
    REGULATION
    Other mRNA expression was progressively up-regulated during differentiation
    ASSOCIATED DISORDERS
    corresponding disease(s) CSBS
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    caused functional obstructions in the intestinal tract and ureter by impaired peristaltic contractions most likely due to a lack of gap-junctional communication between smooth muscle cell
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS