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FLASH GENE
Symbol CCDC34 contributors: mct - updated : 30-11-2022
HGNC name coiled-coil domain containing 34
HGNC id 25079
Corresponding disease
SPGF76 spermatogenic failure 76
Location 11p14.1      Physical location : 27.360.060 - 27.384.795
Synonym name NY-REN-41 antigen
Synonym symbol(s) L15, RAMA3, NY-REN-41, SPGF76
DNA
TYPE functioning gene
STRUCTURE 24.70 kb     6 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 splicing 1422 - 373 - 2000 11173847
3 splicing 2090 26 229 - 2000 11173847
  • lacking several 3' coding exons compared to variant 1
  • EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach   moderately
    Lymphoid/Immunethymus   highly
    Reproductivefemale systemuteruscervix lowly
     male systemtestis  lowly
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • potential oncogenic role for CCDC34 in bladder carcinoma pathogenesis
  • promotes cell proliferation and invasive properties in human cancer
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPGF76
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    predicted the poor outcomes among hepatocellular carcinoma (HCC) patients
    tumoral     --over  
    in bladder cancer tissues and cell lines
    tumoral     --over  
    in pancreatic adenocarcinoma compared with normal pancreatic tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • will become a promising prognostic biomarker and therapeutic target against HCC
  • may serve as a biomarker for bladder cancer
  • increased CCDC34 expression was an independent predictor of poor patient prognosis in pancreatic adenocarcinoma
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveliver
    promising therapeutic target against HCC
    cancerurinary 
    therapeutic target for bladder cancer
    ANIMAL & CELL MODELS