Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CDADC1 contributors: mct/npt - updated : 12/11/2008
HGNC name cytidine and dCMP deaminase domain containing 1
HGNC id 20299
Location 13q14.2      Physical location : 49.822.046 - 49.867.622
Synonym name
  • protein kinase NYD-SP15
  • testis development protein NYD-SP15
  • Synonym symbol(s) NYD-SP15, RP11-103J18.2, MGC150615, MGC41774, MGC57136, bA103J18.1
    DNA
    TYPE functioning gene
    STRUCTURE 45.52 kb     10 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 3364 58.3 514 - Liu (2006)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    Reproductivemale systemtestis  highly
    Visualeye   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two dCMP_cyt_deam domains, indicating a potential functional role for zinc ion binding
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies ortholog to murine Cdadc1
    Homologene
    FAMILY
  • cytidine and deoxycytidylate deaminase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • mainly cytoplasmic
  • small amount found in the nucleus
  • basic FUNCTION
  • DNA deaminase (cytidine deaminase)
  • mediating a form of innate resistance to retroviral infections by triggering G-to-A hypermutation in the newly synthetized viral DNA
  • may play an important role in testicular development and spermatogenesis and may be an important factor governing male infertility
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor,
  • Zn2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS