basic FUNCTION
| Na+ (and Cl-) dependent plasma membrane transporter of gamma-aminobutyric acid (GABA) |
|
may contribute to determining GABA levels in the extracellular space |
|
major regulator in maintaining a gamma-aminobutyric acid reservoir in the CNS, playing negative roles in experimental autoimmune encephalomyelitis pathogenesis |
|
main plasma membrane GABA transporter in brain tissue, mediates translocation of GABA from the extracellular to the intracellular space |
|
role of SLC6A1 in controlling GABBR1-mediated signaling is markedly different from its regulation of GABBR1-mediated fast synaptic transmission |
|
mediates electrogenic transport of GABA together with sodium and chloride |
|
functional interaction of the external and internal gates of SLC6A1 is essential for transport |
|
plays a critical role in the regulation of rapid eye movement (REM) sleep and homeostasis of non-REM (NREM) sleep |
|
sodium- and chloride-coupled GABA transporter and a member of the neurotransmitter:sodium:symporters, which are crucial for synaptic transmission |
|
is one of the major gamma-aminobutyric acid (GABA) transporters in the brain and is responsible for re-uptake of GABA from the synapse |
|
GABBR1, encoding the GABAB1 receptor subunit, and SLC6A1, encoding the neuronal gamma-aminobutyric acid (GABA) transporter GAT1, play a role in addiction by modulating synaptic GABA |