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FLASH GENE
Symbol CHPF contributors: mct/npt - updated : 22-04-2009
HGNC name chondroitin polymerizing factor
HGNC id 24291
Location 2q36.1      Physical location : 220.403.669 - 220.408.487
Synonym name
  • chondroitin sulfate synthase 2
  • glucuronosyl-N-acetylgalactosaminyl-proteoglycan
    • 4-beta-N-acetylgalactosaminyltransferase II
  • chondroitin glucuronyltransferase II
    • Synonym symbol(s) CSS2, FLJ22678, CHSY2
    EC.number 2.4.1.175, 2.4.1.226
    DNA
    TYPE functioning gene
    STRUCTURE 4.76 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    SLC23A3 2q36.1 solute carrier family 23 (nucleobase transporters), member 3 CGI-57 2q36.1 hypothetical protein CGI-57 MGC3035 LOC130617 2q36.1 hypothetical protein BC018415 ABCB6 2q33-q36 ATP-binding cassette, sub-family B (MDR/TAP), member 6 FLJ22169 2q36.1 hypothetical protein FLJ22169 FLJ10415 2q36.1 hypothetical protein FLJ10415 MGC10771 STK16 2q34-q37 serine/threonine kinase 16 TUBA1 2q36.1 tubulin, alpha 1 (testis specific) TUBA4 2q36.2 tubulin, alpha 4 DNAJB2 2q32-q34 DnaJ (Hsp40) homolog, subfamily B, member 2 PTPRN 2q35-q36.1 protein tyrosine phosphatase, receptor type, N LOC389075 2 similar to REGULATED ENDOCRINE SPECIFIC PROTEIN 18 PRECURSOR DNPEP 2q36.3 aspartyl aminopeptidase DES 2q35 desmin APEG1 2q34 desmin LOC389076 2 similar to CAVP-target protein (CAVPT) GMPPA 2q36.1 GDP-mannose pyrophosphorylase A ACCN4 2q36.1 amiloride-sensitive cation channel 4, pituitary CHPF 2q36.1 chondroitin polymerizing factor LOC130612 2q36.1 similar to RIKEN cDNA A230078I05 gene KIAA0657 2q36.1 similar to RIKEN cDNA A230078I05 gene INHA 2q33-q34 inhibin, alpha STK11IP 2q36 serine/threonine kinase 11 interacting protein SLC4A3 2q36 solute carrier family 4, anion exchanger, member 3
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 3013 85.5 775 - Izumikawa (2007)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach    
    Lymphoid/Immunethymus    
    Reproductivefemale systemovary   
     female systemuteruscervix  
    Respiratoryrespiratory tractlarynx   
    Skin/Tegumentskin    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a domain containing beta 3-glycosyltransferase motif but lacked a typical beta 4-glycosyltransferase motif, which is the same as chondroitin sulfate glucuronyltransferase
    • HOMOLOGY
    Homologene
    FAMILY
  • chondroitin N-acetylgalactosaminyltransferase family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    text typical type II membrane protein
    basic FUNCTION
  • required for chondroitin polymerizing activity of chondroitin synthase
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interactions between any two of CHSY1, CHSY3 and CHPF (co-expression of CHSY1 with CHPF resulted in a marked augmentation of glycosyltransferase activities and the expression of the chondroitin polymerase activity of HSY1)Izumikawa 2007)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS