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FLASH GENE

Symbol

HINFP

contributors: mct/npt - updated : 08-06-2022

HGNC name	histone H4 transcription factor
HGNC id	17850

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	11q23.3      Physical location : 118.992.287 - 119.005.764
Synonym name	MBD2-interacting zinc finger 1
	histone H4 gene-specific protein HiNF-P
	MBD2 (methyl-CpG-binding protein)-interacting zinc finger protein
	histone nuclear factor P
Synonym symbol(s)	HiNF-P, MIZF, DKFZp434F162, ZNF743

DNA

TYPE	functioning gene
STRUCTURE	14.48 kb     10 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_015517 11 - 3302 NP_056332 - 517 - 2009 19170105 NM_198971 10 - 3185 NP_945322 - 517 - 2009 19170105 NM_001351958 11 - 3312 NP_001338887 - 517 - 2009 19170105 NM_001351957 10 - 3264 NP_001338886 - 540 - 2009 19170105 NM_001351959 10 - 3195 NP_001338888 - 517 - 2009 19170105 NM_001351971 13 - 3588 NP_001338900 - 270 - 2009 19170105 NM_001351960 12 - 3533 NP_001338889 - 517 - 2009 19170105 NM_001351965 13 - 3455 NP_001338894 - 270 - 2009 19170105 NM_001351974 12 - 3357 NP_001338903 - 270 - 2009 19170105 NM_001351966 12 - 3338 NP_001338895 - 270 - 2009 19170105 NM_001351964 11 - 3283 NP_001338893 - 311 - 2009 19170105 NM_001351972 11 - 3240 NP_001338901 - 270 - 2009 19170105 NM_001351969 10 - 3049 NP_001338898 - 270 - 2009 19170105 NM_001351963 9 - 2994 NP_001338892 - 311 - 2009 19170105 NM_001351961 11 - 2438 NP_001338890 - 445 - 2009 19170105 NM_001351962 10 - 2321 NP_001338891 - 445 - 2009 19170105 NM_001243259 10 - 2243 NP_001230188 - 419 - 2009 19170105

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine         liver       highly Lymphoid/Immune spleen       highly Nervous brain       highly Urinary kidney

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	seven zinc finger domains similar to the C2H2 zinc finger motif
	a stretch of negatively charged amino acids
	specific conserved region (PSCR) located within the C-terminus that is present in HINFP homologues of all metazoan species, required for activation of histone H4 gene transcription and contributing to DNA binding of HINFP (Medina 2008)

HOMOLOGY

Homologene

FAMILY

zinc finger transcription factor family

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleoplasm,nuclear bodies
	intracellular,nucleus,nucleolus

basic FUNCTION	playing a role in DNA methylation and transcription repression
	HiNFP-dependent stabilization of NPAT may reinforce signaling through the cyclin E/CDK2/NPAT pathway and contribute to coordinate control of histone gene expression (Medina 2006)
	unique cell cycle regulatory member of the zinc finger transcription factor family (Medina 2008)
	in addition to histone genes, also regulates expression of nonhistone targets that influence competency for cell cycle progression (Medina 2007)
	bifunctional transcriptional regulator that can activate or repress cell cycle controlled genes depending on the cellular context (Mitra 2007)
	final and essential link in the CCNE1/CDK2/NPAT/HINFP pathway that is required for cell cycle-dependent activation of histone H4 genes at the G1/S phase transition (Xie 2009)
	regulator of histone H4 gene expression in all proliferating cell types and is essential for embryonic survival beyond the blastocyst stage (Xie 2009)
	acting as a unique and irreplaceable transcription factor that functions as part of a CDK2 responsive gene regulatory mechanism that controls progression beyond the G1/S phase transition (Xie 2009)
	mediates cell cycle control of histone H4 gene expression to support the packaging of newly replicated DNA as chromatin
	simultaneous loss of both HINFP and the TP53 checkpoint is detrimental to normal cell growth and may predispose to cellular transformation

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interacting with methyl-CpG-binding protein-2 (MBD2)
	with its cofactor p220(NPAT) are principal factors regulating histone gene expression at the G(1)-S phase cell cycle transition (Medina 2007)
	HINFP is a co-activator in SREBF-mediated transactivation of PCSK9 gene expression
	is essential for expression of histone H4 genes
	transmission of maternal HINFP transcripts and zygotic activation of the HINFP gene together are necessary to control H4 gene expression in early pre-implantation embryos in order to support normal embryonic development
	is a physiological regulator of Histone1-dependent silencing of most transposable elements, as well as many host genes

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   associated with senescence in bladder cancer (BC) tissues and lower HINFP expression could predict an unfavorable outcome in BC patients

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS