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FLASH GENE
Symbol MAGEE1 contributors: mct - updated : 19-05-2020
HGNC name melanoma antigen family E, 1
HGNC id 24934
Location Xq13.3      Physical location : 75.648.045 - 75.651.744
Synonym name
  • alpha-dystrobrevin-associated MAGE protein
  • Hepatocellular carcinoma-associated antigen 1
  • MAGE-E1 antigen
  • cancer/testis antigen 10
  • dystrobrevin-associated MAGE protein
  • Synonym symbol(s) HCA1, DAMAGE, KIAA1587
    DNA
    TYPE functioning gene
    STRUCTURE 3.63 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 3633 103 957 - 2013 23268337
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainlimbic systemhippocampus highly Homo sapiens
    Urinarybladder   lowly
     kidney     Mus musculus
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal   Homo sapiens
    Nervousperipherous    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron Homo sapiens
    NervousPurkinje cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a potential nuclear localization signal
  • 30 12-amino acid repeats
  • two MAGE homology domains
  • HOMOLOGY
    interspecies ortholog to murine Magee1
    Homologene
    FAMILY
  • MAGE family
  • CATEGORY antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    intracellular,nuclear envelope
    basic FUNCTION
  • may play a signaling role in brain, muscle, and peripheral nerve
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MAGEE1 associates directly with alpha-dystrobrevin (DTNA)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveliver
    may provide a promising therapeutic strategy for HCC treatment
    ANIMAL & CELL MODELS