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FLASH GENE

Symbol

POLR3E

contributors: - updated : 14-03-2005

HGNC name	(RNA) III (DNA directed) polypeptide E (80kD)
HGNC id	30347

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	16p12.1      Physical location : 22.308.740 - 22.345.341
Synonym symbol(s)	SIN, RPC5, KIAA1452
EC.number	2.7.7.6

DNA

TYPE	functioning gene
STRUCTURE	36.00 kb     19 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 - splicing 2127 variant 1 79 708 - Ota, Hu variant 2 - splicing - variant 2 74 666 - Ota, Hu variant 3 - splicing - variant 3 73 654 - Nagase

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine     highly   stomach       highly Lymphoid/Immune lymph node       highly   thymus       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

complex

HOMOLOGY

interspecies	ortholog to murine Polr3e
	ortholog to yeast C37 subunit

Homologene

FAMILY

CATEGORY

enzyme , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
	essential for efficient transcription from both the type 2 VAI and type 3 U6 RNA polymerase III promoters
	involved in the regulation of cell cycle

CELLULAR PROCESS	cell cycle
	nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

nucleic , other

signaling

tRNA metabolism

a component

component of the RNA polymerase III complex which consists of about 15 different subunits

INTERACTION

DNA

binding

RNA

small molecule

protein

POLR3D

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS