basic FUNCTION
| involved in controlling the correct subcellular localization of integral membrane proteins containing acidic cluster sorting motifs |
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combined with Nef, usurping the ARF6 endocytic pathway by a PI3K-dependent process to remove cell surface MHC-I molecules |
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playing a putative role in the localization of trans-Golgi network (TGN) membrane proteins retrograde and anterograde |
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Golgi |
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endosome transport |
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plays a role in HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the TGN |
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recruits CK2 to phosphorylate Ser278, thereby regulating cargo binding |
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has a role in the recycling of internalized cargo from early endosomes to the cell surface and trafficking of cargo to the primary cilium in epithelial cells |
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targets nephrocystin to the base of primary cilium |
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regulates GGA3 binding to cargo |
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role in the ciliary trafficking of the olfactory cyclic-nucleotide-gated (CNG) channel |
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intracellular sorting protein that mediates its effects through the binding of acidic clusters on cargo protein |
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trans-Golgi-membrane regulator that directs phosphorylated cargo molecules |
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is potentially necessary for the formation of craniofacial structures and that perturbation of its functions results in a specific syndromic intellectual disability phenotype |
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trans-golgi-membrane traffic regulator |