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FLASH GENE
Symbol ISY1 contributors: mct - updated : 20-02-2013
HGNC name ISY1 splicing factor homolog (S. cerevisiae)
HGNC id 29201
Location 3q21.3      Physical location : 128.848.234 - 128.880.029
Synonym name
  • KIAA1160 protein
  • pre-mRNA-splicing factor ISY1 homolog
  • functional spliceosome-associated protein 33
  • Synonym symbol(s) KIAA1160, FSAP33
    DNA
    TYPE functioning gene
    STRUCTURE 33.81 kb     11 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 5068 - 331 - 2009 19789211
    11 - 3778 - 285 - 2009 19789211
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    Lymphoid/Immunespleen   moderately
    Nervousbraindiencephalonamygdala moderately
     brainhindbraincerebellum moderately
    Reproductivefemale systemovary  highly
    Respiratorylung   highly
    Skin/Tegumentskin   highly
    Urinarykidney   moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • ISY1 family
  • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • implicated in the first catalytic step of splicing and splicing fidelity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with the ATPase DHX38 to regulate the fidelity of pre-mRNA splicing
  • multiple functions for SRRM2 in the splicing process, including an important role in the activation of splicing in association with ISY1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS