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FLASH GENE
Symbol MORC4 contributors: mct/npt - updated : 07-10-2009
HGNC name MORC family CW-type zinc finger 4
HGNC id 23485
Location Xq22.3      Physical location : 106.183.964 - 106.243.474
Synonym name zinc finger, CW type with coiled-coil domain 2
Synonym symbol(s) ZCW4, FLJ11565, ZCWCC2, OX-TES-4, dJ75H8.2
DNA
TYPE functioning gene
STRUCTURE 59.48 kb     14 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 3777 - 900 - Ross (2005)
14 - 3815 - 937 - Ross (2005)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepancreasislet of Langerhans  lowly
Reproductivefemale systemplacenta  moderately
 female systemuterus  lowly
 male systemprostate  lowly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a CW-type zinc finger
  • nuclear localisation signals
  • a nuclear matrix-binding domain, together with a coiled-coil region
  • a HATPase-C domain (Liggins 2007)
  • HOMOLOGY
    interspecies homolog to murine Zcwcc2
    Homologene
    FAMILY
  • MORC family
  • CATEGORY antigen
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • potential lymphoma biomarker, whose overexpression may contribute to the immunological recognition of MORC4 by a subgroup of (diffuse large B-cell lymphoma) DLBCL patients (Liggins 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, nucleotide,
  • Zn2+
  • ATP
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in non-germinal centre-derived DLBCL (diffuse large B-cell lymphoma) and Hodgkin lymphoma cell lines, compared with germinal centre-derived DLBCL cell lines and normal B cells (Liggins 2007)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS