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FLASH GENE
Symbol PPRC1 contributors: mct - updated : 19-11-2014
HGNC name peroxisome proliferative activated receptor, gamma, coactivator-related 1
HGNC id 30025
Location 10q24.32      Physical location : 103.892.786 - 103.910.088
Synonym name
  • RP11-302K17.6
  • PGC-1 related co-activator
  • Synonym symbol(s) PRC, KIAA0595, MGC74642
    DNA
    TYPE functioning gene
    STRUCTURE 17.34 kb     14 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 5390 - 1664 - 2001 11340167
    12 - 4598 - 1400 - 2001 11340167
    14 - 5283 - 1542 - 2001 11340167
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach   highly
    Respiratoryrespiratory tractlarynx  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelial    
    cell lineage
    cell lines
  • follicular carcinoma
  • four pooled high-grade tumors (including two primary tumors and two metastatic to ovary)
  • prostatic intraepithelial neoplasia (high grade)
  • fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two distinct recognition motifs (separated by an unstructured proline-rich region)
  • an unstructured proline-rich region
  • a N terminal potent transcriptional activation domain (adjacent to an LXXLL motif)
  • an LXXLL motif
  • an activation domain
  • an RS domain
  • an RNA recognition motif
  • HOMOLOGY
    intraspecies paralog to PPARGC1
    Homologene
    FAMILY PGC-1A family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • involved in mitochondrial proliferation
  • serve as inducible coregulator of nuclear receptor in the control of cellular energy metabolic pathways (
  • role in the integration of pathways directing mitochondrial respiratory function and cell growth central transcriptional coactivator that regulate cell metabolic processes ranging from mitochondrial biogenesis to oxidative respiration
  • general role for PRC in the adaptive response to cellular dysfunction
  • growth-regulated transcriptional cofactor known to activate many of the nuclear genes specifying mitochondrial respiratory function
  • is a negative regulator of endothelial inflammation
  • can inhibit adhesion molecule expression and monocyte attachment to activated endothelial cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • NRF1
  • has a transcriptional specificity that is very similar to PPARGC1A, especially in its interaction with NRF1 and in the activation of NRF1 target genes
  • exerts its anti-inflammatory effects via NFKB
  • could prevent endothelial activation through inhibition of NFKB activity
  • cell & other
    REGULATION
    induced by reintroduction of serum
    Other down-regulated in quiescent BALB/3T3 cells
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyinflammatory 
    activation of PPRC1 might be beneficial for many inflammatory diseases associated with endothelial dysfunction
    ANIMAL & CELL MODELS
  • homozygous deficient Pprc1 mice failed to form egg cylinders and died after implantation but before embryonic day 6.5, whereas mice heterozygous for Pprc1 were viable, fertile and indistinguishable from their wild-type littermates