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FLASH GENE
Symbol MAGEH1 contributors: mct - updated : 07-05-2020
HGNC name melanoma antigen family H, 1
HGNC id 24092
Location Xp11.21      Physical location : 55.478.537 - 55.479.998
Synonym name
  • APR-1 protein
  • restin
  • MAGE-H1 antigen
  • apoptosis-related protein 1
  • Synonym symbol(s) APR-1, APR1, MAGEH
    DNA
    TYPE functioning gene
    STRUCTURE 1.44 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 1440 - 219 - 2014 25366798
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvesselaorta   
    Nervousbrainforebraincerebral lobefrontal lobe 
     brainhindbraincerebellumcerebellar cortex 
    Reproductivemale systemprostate   
    Respiratorylung    
    Urinarykidney     Mus musculus
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Membraneserous membranepericardium  
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    one MAGE domain
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • may be involved in apoptosis
  • MAGEH1 associates with the intracellular domain of the NGFR and regulates the cell cycle
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NDN and MAGEH1, are interactors for the intracellular domain of NGFR and the interaction is enhanced by ligand stimulation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in hepatocellular carcinoma (HCC) tumor tissues compared with adjacent normal liver tissues and significantly correlated with poor prognosis in HCC patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • negative expression of MAGEH1 protein serves as a potential predictive marker for the effectiveness of gemcitabine therapy in biliary tract carcinoma (BTC)
  • may serve as a potential biomarker and a new prognostic factor for hepatocellular carcinoma (HCC)
  • aberrant expression patterns of MAGEH1 in teratocarcinoma cells can be considered as specific teratocarcinoma biomarkers promoted the malignant phenotype
  • Therapy target
    ANIMAL & CELL MODELS