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FLASH GENE
Symbol MYLPF contributors: mct/npt - updated : 15-09-2020
HGNC name myosin light chain, phosphorylatable, fast skeletal muscle
HGNC id 29824
Location 16p11.2      Physical location : 30.386.122 - 30.389.310
Genatlas name fast skeletal myosin light chain 2
Synonym name
  • myosin light chain 2
  • myosin regulatory light chain 2, skeletal muscle isoform
  • fast skeletal myosin light chain 2
  • myosin, light chain 11, regulatory
  • Synonym symbol(s) MRLC2, MGC13450, MLC2B, DKFZp779C0757, HUMMLC2B, MYL11
    DNA
    TYPE functioning gene
    STRUCTURE 7.06 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 657 19 169 - 2015 26663899
    9 - 843 - 169 - 2015 26663899
    9 - 847 - 169 - 2015 26663899
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text pancreas
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two EF-hand calcium-binding domains
  • HOMOLOGY
    interspecies ortholog to murine Mylpf
    homolog to zebrafish mylpfa
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • involved in muscle development
  • is critically important for fast and slow skeletal muscle development
  • MYLPF function is essential for muscle integrity during early development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RHOA-mediated MYLPF regulates likely the actin organization for cytokinesis during oocyte maturation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice homozygous for a null mylpf allele lack all skeletal muscle at birth