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FLASH GENE
Symbol SSU72 contributors: mct - updated : 04-04-2011
HGNC name SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae)
HGNC id 25016
Location 1p36.33      Physical location : 1.477.053 - 1.510.262
Synonym name
  • Ssu72 RNA polymerase II CTD phosphatase homolog (yeast)"
  • HSPC182 protein
  • CTD phosphatase SSU72
  • Synonym symbol(s) FLJ13048, PNAS-120, HSPC182, RP5-832C2.2
    DNA
    TYPE functioning gene
    STRUCTURE 33.21 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1319 - 194 - 2010 20818333
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrinepituitary   
     parathyroid    
    Nervousnervecranial nerve   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a unique active-site landscape as well as extra structural features at the C terminus that are important for interaction with symplekin
  • HOMOLOGY
    interspecies ortholog to rattus ssu72
    ortholog to murine Ssu72
    Homologene
    FAMILY
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • potential intervention at the capping checkpoint step of the transcription cycle
  • transcription elongation factor, C-terminal domain (CTD) phosphatase with specificity for serine-5-P
  • role for its C-terminal domain phosphatase in RNA polymerase II transcription elongation
  • having a dual role in transcription, one as a CTD S5-P phosphatase that regenerates the initiation-competent, hypophosphorylated form of RNAP II and the other as a factor necessary for cleavage of pre-mRNA and efficient transcription termination
  • having a role in transcription-coupled pre-mRNA 3prime-end processing
  • regulates the cohesion of chromosome arms but not centromeres, and acts by counteracting the phosphorylation of STAG2
  • cohesin-binding protein capable of regulating cohesion between sister chromatid arms
  • potentially involved in sister chromatid arm cohesion as early as the G2 phase of the cell cycle
  • regulates cohesion at the chromosome arms in a WAPAL-independent manner
  • essential phosphatase conserved in eukaryotes that dephosphorylates phosphorylated Ser5 of the CTD heptapeptide
  • its function is implicated in transcription initiation, elongation and termination, as well as RNA processing
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • a RAD21-binding protein (directly interacts with RAD21 and STAG2)
  • may be involved in the dephosphorylation or hypophosphorylation of STAG2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS