SUBCELLULAR LOCALIZATION
| intracellular
|
| intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
|
| intracellular,nucleus,nucleoplasm
|
| intracellular,nucleus,chromatin/chromosome,heterochromosome
|
| intracellular,nucleus,chromatin/chromosome,centromere
|
| intracellular,nucleus,chromatin/chromosome,kinetochore
|
text
| tightly bound to heterochromatin and heterochromatin protein 1alpha (HP1alpha) and HP1beta in G1 and early S phase, but during late S, G2 and M phases tight chromatin association was restricted to centromeres |
|
also localized to centrosomes throughout the entire cell cycle |
|
present only at the centromeres during late G2 and mitosis |
|
gradually are displaced from chromatin during S phase, ending up exclusively at centric (and in some cells, also telomeric) heterochromatin in mitosis |
|
shortly after fertilization, ORC2 was detectable at the metaphase II spindle poles and then between the separating chromosomes |
|
during zygotic mitosis, ORC2 again localized first to the spindle poles, then to the area between the separating chromosomes |
|
in G1 of the two-cell stage, both nuclei had salt-resistant ORC2 and MCM7 |
basic FUNCTION
| regulator of the initiation of DNA replication and transcription |
|
having a role in both chromosomal replication and mating type transcriptional silencing |
|
implicated in many cellular activities, including DNA replication, transcriptional control, heterochromatin assembly, centromere and telomere function |
|
involved in chromosome duplication, chromosome structure and centrosome copy number control, and may be coordinating all stages of the chromosome inheritance cycle |
|
with ORC3 and CBX5, may be recruited to the chromatin as a single complex and require each other for their stable association to heterochromatin |
|
with CBX5, are required for condensation of centric heterochromatic satellite repeats |
|
involvement of ORC1, ORC2, ORC3 in the maintenance of constitutive heterochromatin |
|
together with CBX proteins may be involved in organizing higher-order chromatin structure and centromere function |
|
its phosphorylation might take place in a cell cycle-dependent manner |
|
depletion of LRWD1 and ORC2 leads potentially to increased transcription of major satellite repeats |
|
conserved role of ORC2 in modulating DNA structure to facilitate origin selection and helicase loading in eukaryotes |