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FLASH GENE
Symbol GFM2 contributors: KTN/npt - updated : 09-01-2009
HGNC name G elongation factor, mitochondrial 2
HGNC id 29682
Location 5q13.3      Physical location : 74.017.030 - 74.063.042
Synonym name elongation factor G2
Synonym symbol(s) EFG2, MST027, FLJ21661, MSTP027
DNA
TYPE functioning gene
STRUCTURE 46.01 kb     22 Exon(s)
regulatory sequence cytosine-phosphate-guanine/HTF
text structure its 5-prime end residing within a CpG island, characteristic of a housekeeping gene
MAPPING cloned Y linked N status confirmed
Map see ENC1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
21 splicing 3111 86.5 779 - Hammarsund
20 splicing 2970 81.1 732 - Hammarsund
  • lacking an alternate in-frame exon in the coding region compared to variant 1
  • lacking an internal aa fragment but has identical N- and C-termini to isoform 1
    • 15 splicing 1962 56.9 513 - Hammarsund
  • lacking several 3' exons and having an alternate 3' end compared to variant 1
    		•
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveliver   highly
    Urinarykidney   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text liver
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to dog GFM2 (90 pc)
    homolog to chimpanzee GFM2 (99.5 pc)
    homolog to cow GFM2 (89.4 pc)
    homolog to rattus Gfm2 (83 pc)
    homolog to murine Gfm2 (84.6 pc)
    Homologene
    FAMILY
  • GTP-binding elongation factor family
  • EF-G/EF-2 subfamily
    • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • promoting the GTP-dependent translocation of the nascent protein chain from the a-site to the p-site of the ribosome
  • having a function in quality control of translation elongation
    • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • GTP
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS