basic FUNCTION
| functioning as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES |
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regulating the translation of reticulocyte 15-lipoxygenase (ALOX15) mRNA |
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promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure |
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implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA |
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playing a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability |
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can function as a cytosolic iron chaperone in the delivery of iron to ferritin |
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functions as a RNA-binding, as well as DNA-binding, protein |
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bifunctional protein acting as both an iron-binding and an RNA binding protein |
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PCBP1 plays a major role in the dynamic expression of AR in both male and female androgen-responsive cells |
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physiologically relevant, sensitive, cellular sensor of folate deficiency |
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iron chaperone that binds iron and delivers it to ferritin, a cytosolic iron storage protein |
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required for iron incorporation into prolyl hydroxylase |
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broad role for PCBP1 and PCBP2 in delivering iron to cytosolic nonheme iron enzymes |
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critical role of PCBP1 in regulating mitochondrial antiviral signaling for both fine-tuning the antiviral immunity and preventing inflammation |
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may be important in the pathogenesis of gestational trophoblastic tumors |
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PCBP1 and PCBP2 may serve as iron chaperones to multiple classes of cytosolic nonheme iron enzymes and may have a particular role in restoring metal cofactors that are spontaneously lost in iron deficient cells |
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importance of ferritin for the vectorial transfer of imported iron to mitochondria in developing red cells and of PCBP1 and NCOA4 in mediating iron flux through ferritin |
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roles of PCBP1 and nuclear coactivator 4 (NCOA4) in mediating the flux of iron through ferritin in developing erythroid cells |