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FLASH GENE
Symbol EXOSC1 contributors: mct - updated : 08-07-2013
HGNC name exosome component 1
HGNC id 17286
Location 10q24.2      Physical location : 99.195.666 - 99.205.768
Synonym name
  • exosomal core protein CSL4
  • ribosomal protein S1-like RNA-binding domain;
  • Synonym symbol(s) p13, CSL4, SKI4, Csl4p, Ski4p, CGI-108
    DNA
    TYPE functioning gene
    STRUCTURE 10.10 kb     8 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1150 - 195 - 2002 11812149
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier liningepidermis  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymphocyte
    Skin/Tegumentcornified cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    one S1 RNA-binding motif
    mono polymer heteromer , tetramer
    HOMOLOGY
    interspecies ortholog to S. cerevisiae CSL4
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • core component of the exosome, required for rapid degradation of AU rich element-containing RNAs but not for poly(A) shortening
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the exosome, a complex of 3'-5'exoribonucleases
  • association of this protein with the exosome is mediated by protein-protein interactions with ribosomal RNA-processing protein 42 and ribosomal RNA-processing protein 46
  • trimer of EXOSC1 or EXOSC2 subunits forms a multidomain macromolecular interaction surface on the RNase-PH domain ring with central S1 domains and peripheral KH and zinc-ribbon domains
  • INTERACTION
    DNA
    RNA RNA binding
    small molecule
    protein
  • N- and C-terminal regions required for interaction with EXOSC5
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS