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FLASH GENE
Symbol IL31RA contributors: npt/SGE - updated : 06-04-2010
HGNC name interleukin 31 receptor A
HGNC id 18969
Location 5q11.2      Physical location : 55.147.333 - 55.212.980
Synonym name
  • gp130-like monocyte receptor
  • soluble type I cytokine receptor CRL3
  • class I cytokine receptor
  • Synonym symbol(s) GPL, GLMR, CRL3, IL-31RA, CRL
    DNA
    TYPE functioning gene
    STRUCTURE 65.65 kb     15 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 2393 - 764 - Ghilardi (2002)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunethymus   lowly
    Nervousbrain   lowly
    Reproductivefemale systemovary  lowly
     female systemplacenta  lowly
     male systemtestis  lowly
     male systemprostate  lowly
    Respiratoryrespiratory tracttrachea  lowly
    Skin/Tegumentskin   lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticgranulocyte
    Blood/Hematopoieticmonocyte
    Lymphoid/Immunedendritic cell
    cell lineage
    cell lines constitutively expressed in epithelial cells
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • five fibronectin type III domains
  • conjugated GlycoP
    mono polymer homomer , heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • type I cytokine receptor family
  • type 2 subfamily
  • CATEGORY immunity/defense , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • signaling receptor chain potentially involved in the development and function of monocytes and macrophages
  • strong activator of STAT3 and STAT5
  • in the heterodimeric configuration, activating MAPK3 and MAPK1 (Dreuw 2004)
  • may function in skin immunity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forming an heterodimeric receptor with OSMR for IL31 signals
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with JAK1, STAT3
  • cell & other
    REGULATION
    induced by IFNG in activated monocytes
    LPS
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    up-regulated in lesional keratinocytes of patients with atopic dermatitis
    Susceptibility
    Variant & Polymorphism other
  • a C15C2C>T mutation leading to missense mutation is associated with a case of familial primary cutaneous amyloidosis (Lin 2010)
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS