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FLASH GENE
Symbol CTAG1B contributors: mct/npt - updated : 10-06-2020
HGNC name cancer/testis antigen 1B
HGNC id 2491
Location Xq28      Physical location : 153.813.417 - 153.847.522
Synonym name
  • New York esophageal squamous cell carcinoma 1
  • autoimmunogenic cancer/testis antigen NY-ESO-1
  • L antigen family member 2
  • Synonym symbol(s) CTAG, ESO1, LAGE2B, CTAG1, NY-ESO-1, CT6, CT6.1, LAGE2A
    DNA
    TYPE functioning gene
    STRUCTURE 1.66 kb     3 Exon(s)
    motif repetitive sequence   other
    text structure two copies in the NEMO (IKBKG) / LAGE2 duplication, in opposite orientations
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 752 - 180 - 2019 31158427
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemovary   
     male systemtestis   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivegerm cell
    cell lineage
    cell lines a proportion of human cancers in a lineage non specific fashion and myeloma cells
    fluid/secretion
    at STAGE
    physiological period fetal, perinatal
    Text in oocytes its expression persisted through the neonatal stage (Gjerstorff 2007)
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal glycine rich region
  • a putative C terminal transmembrane domain with two alternative transcripts
  • HOMOLOGY
    Homologene
    FAMILY
  • NY-ESO-1 gene family
  • CTAG family
  • CATEGORY antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • regulating actin polymerization by stimulating the actin-nucleating activity of the actin-related protein 2/3 (arp2/3) complex
  • with GAGE1, are associated with highly proliferating germ cells (Gjerstorff 2007)
  • vital association is exist between the epithelial mesenchymal transition (EMT) and the acquisition of cancer stemness state in tumor cells through the TWIST1/CTAG1B axis and it can be a critical hallmark in esophageal squamous cell carcinoma (ESCC) tumorigenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    expressed in hepatocellular carcinoma (Wang 2009)
    tumoral     --over  
    increases as the malignancy grade of the astrocytic tumors increases (Bodey 2008)
    tumoral     --over  
    in patients with synovial sarcoma and myxoid liposarcoma
    tumoral     --other  
    expressed in Triple Negative breast cancer (TNBC)
    tumoral     --over  
    in the vast majority of myxoid liposarcomas, and their high-level expression correlated with tumour grade and poor prognosis
    tumoral     --other  
    association between CTAG1B expression and an aggressive ovarian cancer phenotype
    tumoral     --over  
    was positively correlated with higher grade and patients presenting with higher levels of CTAG1 staining had significantly worse disease-free and overall survival in meningioma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • potential utility of MAGEA4 as an ancillary diagnostic marker for synovial sarcoma combined with CTAG1B
  • CTAG1B and MAGEA4 may be useful for the diagnosis of synovial sarcoma
  • Therapy target
    ANIMAL & CELL MODELS