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FLASH GENE
Symbol GATAD2A contributors: mct - updated : 22-11-2013
HGNC name GATA zinc finger domain containing 2A
HGNC id 29989
Location 19p13.11      Physical location : 19.496.641 - 19.619.740
Synonym name
  • p66 alpha
  • transcriptional repressor p66 alpha
  • Synonym symbol(s) FLJ20085, P66ALPHA
    DNA
    TYPE functioning gene
    STRUCTURE 123.10 kb     12 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 5689 - 633 - 2002 1218346
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas    
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratorylung    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumentmelanocyte
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    physiological period fetal
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one GATA-type zinc finger
  • a conserved region 2 that is required for histone tail interaction as well as for wild-type subnuclear distribution
  • HOMOLOGY
    interspecies homolog to murine Gatad2a (91.6pc)
    homolog to rattus Gatad2a (92.2pc)
    intraspecies paralog to GATAD2B
    Homologene
    FAMILY p66 family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    basic FUNCTION
  • involved in methylation dependent transcriptional repression
  • is essential for development
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of a complex containing MBD2, HDAC1 and/or HDAC2
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding MBD3, P66BETA
  • GATAD2A, GATAD2B interact with MBD2 functionally and biochemically
  • a coiled-coil interaction between MBD2 and GATA2A proteins recruits the chromodomain helicase DNA-binding protein (CHD4) to the NuRD complex and is necessary for MBD2-mediated DNA methylation-dependent gene silencing
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS