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FLASH GENE
Symbol PLXNB1 contributors: mct - updated : 14-01-2016
HGNC name plexin B1
HGNC id 9103
Location 3p21.31      Physical location : 48.445.260 - 48.471.460
Synonym name
  • plexin 5
  • semaphorin receptor
    • Synonym symbol(s) KIAA0407, PLXB1, SEP, PLXN5
    DNA
    TYPE functioning gene
    STRUCTURE 26.23 kb     38 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map pter - D3S1313 - D3S643 - D3S1561 - PLXNB1 - D3S3179 - D3S3444 - D3S3150 - D3S4068 - D3S4064 - D3S4023 - cen
    Authors Genemap (99)
    RNA
    TRANSCRIPTS type messenger
    text
  • two alternatively truncated spliced variant, coding secreted proteins (lacking the part of the extracellular domains) (Tamagnone, 99)
    • identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    38 - 7158 - 2135 - 2002 12220504
    38 - 7325 - 2135 - 2002 12220504
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
     intestinelarge intestinecolon highly
    Endocrinethyroid   highly
    Nervousbrain   highly
     nerve   highly
    Reproductivemale systemprostate  highly
    Respiratoryrespiratory tractlarynx  predominantly
     respiratory tracttrachea  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/lining   
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell
    Nervousneuron
    cell lineage hematopoietic cells
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text highly in kidney
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a Sema domain
  • three IPT/TIG domains
  • a RHO binding domain (B1RBD)
    • conjugated GlycoP , PhosphoP
    mono polymer heteromer , monomer , dimer
    HOMOLOGY
    interspecies homolog to rattus Plxnb1 (87 pc)
    homolog to murine Plxnb1 (87.3 pc)
    intraspecies homolog to the hepatocyte growth factor receptor family
    Homologene
    FAMILY
  • calcium-dependent cell adhesion molecule family
  • plexin family
    • CATEGORY receptor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text
  • single-pass type I membrane protein
    • basic FUNCTION
  • acting as a receptor for SEMA4D
  • playing a role in RHOA activation and subsequent changes of the actin cytoskeleton
  • playing a role in axon guidance, invasive growth and cell migration
  • promoting binding of cytoplasmic ligands by the interaction with SEMA4D
  • having a role in prostate cancer progression
  • SEMA4D/PLXNB1 promotes the dephosphorylation and activation of PTEN through the RRas GAP activity, inducing growth cone collapse
  • SEMA4D/PLXNB1-mediated NFKB1 activation and IL8 production is critical in the generation a pro-angiogenic phenotype in endothelial cells
  • role for PPLXNB1 in maintenance of melanocyte survival and proliferation in the skin, suggesting that SEMA4D and PLXNB1 act cooperatively with HGF and MET to regulate MET-dependent effects in human melanocytes
  • PLXNB1 and SEMA4D cooperate to promote perineural invasion in a RHOA/ROK-dependent manner
  • SEMA4D receptor PXNBB1 induces repulsion in axon and dendrites by functioning as a GTPase-activating protein (GAP) for RRAS and MRAS, respectively
    • CELLULAR PROCESS cell life, differentiation
    cell migration & motility
    PHYSIOLOGICAL PROCESS
    text
  • positive regulation of axonogenesis
    • PATHWAY
    metabolism
    signaling signal transduction
    a component
  • monomer
  • heterodimer with PLXNB2 after proteolytic processing
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding specifically to the GTP binding activated RAC1
  • binding to ARHGEF11, ARHGEF12, ERBB2, MET, MST1R, RND1, NRP1 and NRP2
  • binding to PLXNA1
  • interacting with SEMA4D (its ligand)
  • SEMA4D, enhances tumor cell motility through binding its receptor, PLXNB1, in pancreatic cancer
  • SEMA4D/PLXNB1-mediated MRas GAP activity regulates actin-based dendrite remodeling through RAPH1
  • binds in a GTP-dependent manner to RAC1, RAC2, RAC3, RND1, RND2, RND3, and RHOD
  • SEMA4D act through its receptor PLXNB1 to regulate axon growth cone guidance, lymphocyte activation, and bone density
  • SEMA3C drives activation of multiple RTKs including EGFR, ERBB2, and MET in a cognate ligand-independent manner via PLXNB1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral somatic mutation      
    in localized and metastatic prostate carcinoma
    tumoral     --over  
    in prostate carcinoma
    tumoral     --over  
    significantly higher in serous ovarian carcinomas than in normal ovaries
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveovary
    might be a useful biomarker and/or a novel therapeutic target in ovarian carcinoma
    ANIMAL & CELL MODELS