motifs/domains
| a short cytoplasmic domain, with key AAs within its cytoplasmic tail that are important in sequestering the enzyme within the cell , necessary for its regulation |
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a scavenger receptor cysteine-rich (SRCR) domain, and a serine protease domain |
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a type II transmembrane sequence |
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a central region with several modular structural domains including two CUB (complement factor C1s/C1r, urchin embryonic growth factor, bone morphogenetic protein) domains and three low density lipoprotein receptor tandem repeats |
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a C-terminal catalytic domain |
SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,organelle,endosome
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| intracellular,cytoplasm,organelle,lysosome
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text
| endocytosed TMPRSS6 next transited in early endosomes and then to lysosomes |
basic FUNCTION
| may be involved in proteolysis and peptidolysis |
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may be playing a specialized role in matrix remodeling processes taking place in this tissue during development or in adult tissues |
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putative role of matriptase-2/TMPRSS6 in iron homeostasis |
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may be involved in matrix remodeling processes in the liver |
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negatively regulates the expression of the systemic iron regulatory hormone hepcidin and is essential for normal systemic iron homeostasis (may cleave a protein that acts in or on hepatocytes to negatively regulate hepcidin production, secretion, or clearance) |
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regulator of hepcidin synthesis and iron handling, that is crucial in hemoglobin level maintenance |
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involvement of TMPRSS6 in control of iron homeostasis and in normal erythropoiesis |
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controls iron homeostasis through its negative regulation of expression of hepcidin |
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controls iron homeostasis through its negative regulation of expression of hepcidin |
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importance of TMPRSS6 trafficking at the plasma membrane in the regulation of hepcidin expression, an event that is essential for iron homeostasis |
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TMPRSS6 cleavage of HFE2 occurs either at the cell surface or during a retrograde trafficking to the TGN/Golgi compartment in a NEO1-dependent manner |
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has the ability to suppress the angiogenic nature of HECV (human vascular endothelial cells), suggesting that it could have a potential role in prostate and breast tumour suppression through its anti-angiogenic properties |
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is the key enzyme of iron homoeostasis modulating the expression of the liver peptide hormone HAMP |
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crucial role in the regulation of iron homeostasis by inhibiting HAMP expression |
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is a critical participant in retinal iron homeostasis |
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hepatic membrane serine protease that regulates iron homeostasis |
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type II transmembrane serine protease controlling the expression of hepcidin, the key regulator of iron homeostasis |
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regulates HAMP expression by cleaving hemojuvelin (HFE2), a bone morphogenetic protein (BMP) coreceptor in the hepcidin regulatory pathway |