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FLASH GENE
Symbol EME2 contributors: npt/mct - updated : 23-01-2019
HGNC name essential meiotic endonuclease 1 homolog 2 (S. pombe)
HGNC id 27289
Location 16p13.3      Physical location : 1.823.228 - 1.826.238
Synonym name homolog of yeast EME1 endonuclease 2
Synonym symbol(s) FLJ00151, gs125, SLX2B
EC.number 3.1.22.-
DNA
TYPE functioning gene
STRUCTURE 3.49 kb     8 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 1140 - 379 - 2014 24813886
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C-terminal ERCC4 nuclease domain
  • an HhH domain (Ciccia 2007)
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to yeast Eme1 endonuclease 2
    Homologene
    FAMILY
  • EME1/MMS4 family
  • CATEGORY enzyme , unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • having an endonuclease activity
  • MUS81 WH domain mutation greatly reduce binding of the isolated domain to DNA and impact on incision activity of MUS81-EME1/EME2 complexes)
  • MUS81-EME1 and MUS81-EME2 exhibit similar and yet distinct DNA structure selectivity, indicating that the two MUS81 complexes may promote different nucleolytic cleavage reactions
  • MUS81-EME2 catalyzed cleavage of nicked and gapped duplex deoxyribonucleic acids (DNAs), generating double-strand breaks
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimer with MUS81 (Ciccia 2007)
  • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • target of MUS81
  • both MUS81-EME1 and MUS81-EME2 increased the activity of FEN1, but FEN1 did not stimulate the activity of MUS81-EME1/EME2
  • MUS81-EME2 protein, whose actions are restricted to S phase, is also responsible for telomere maintenance in telomerase-negative ALT (Alternative Lengthening of Telomeres) cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS