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FLASH GENE
Symbol CCR1 contributors: mct - updated : 06-05-2020
HGNC name chemokine (C-C motif) receptor 1
HGNC id 1602
Location 3p21.31      Physical location : 46.243.199 - 46.249.832
Synonym name
  • small inducible cytokine (SCYA3, SCYA5, SCYA7) common receptor
  • macrophage inflammatory protein 1-alpha receptor
  • LD78 receptor
  • RANTES receptor
  • CD191 antigen
  • Synonym symbol(s) CMKBR1, CKR-1, HM145, MIP1aR, SCYAR1, CD191, RANTES-R, C-C CKR-1, CMKR1
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 6.60 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 2690 - 355 - 2018 29285854
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas   highly
    Reproductivefemale systemplacenta  highly
    Respiratorylung   highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticplatelet
    Skeletonosteoblast Homo sapiens
    Skeletonosteoclast Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven transmembrane segments (7TM) receptor
  • HOMOLOGY
    interspecies homolog to cmkbr1
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
  • CATEGORY signaling , receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • playing a role in host protection from inflammatory response, and susceptibility to virus and parasite
  • having an important regulatory role in colon cancer progression
  • in collaboration with CCL23, mediates endothelial cell migration
  • CCL3/CCR1 axis may have a role in the spread of tumoral cells to the lymph nodes and also in the local host defense against the tumor
  • play an important role in the host response to pathogens
  • plays a critical role in the recruitment of leukocytes to the site of inflammation
  • regulates inflammatory cell infiltration after renal ischemia-reperfusion injury
  • role for a role for CCR1 signaling in the pathogenesis of hematolymphoid neoplasia
  • CCR1 signaling mediated by its ligands (CCL4, CCL5, CCL 9, and CCL11) plays an essential role in mineralized nodule formation
  • plays a critical role on osteoblast-osteoclast communication through the regulation of the TNFRSF11A and TNFSF11A expression
  • its activation may potentially play a role in the photoreceptor apoptosis
  • chemokine signaling via CCR1 may be involved in regulation of stemness of adipose tissue derived stromal cells (ADSCs)
  • CCR1 exhibits significant constitutive activity leading to a variety of cellular responses, and its expression is sufficient to induce inhibition of cAMP formation, increased F-actin content, and basal migration of leukocytes
  • CCR1 mediates trafficking of leukocytes to sites of inflammation
  • CCR1 functions likely to significantly modulate pain by controlling neutrophil trafficking to the inflammatory site and having an unexpected role on non-hematopoietic cells
  • potential role of CCR1, CCR3 genes in narcolepsy
  • expression levels of CCR1, CCR5 were higher in bone marrow mast cell progenitors (MCp) than in the peripheral blood, suggesting that CCR1 and CCR5 may mediate retention in the bone marrow
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • high affinity binding for monocyte chemoattractant protein 3
  • interaction between CCR1 and its ligands, CCL5 and CCL9, could be involved in osteoclast differentiation
  • CCL15 is a CC chemokine that binds to the CCR1 and CCR3
  • macrophages confer survival signals via CCR1-dependent translational MCL1 induction in chronic lymphocytic leukemia
  • cell & other
    REGULATION
    induced by SPP1 (CCR1 and CXCR6 are the most upregulated chemokine receptors induced by SPP1) (
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in Alzheimer's disease (early and specific marker)
    tumoral     --over  
    in invasive intestinal tumors
    tumoral     --over  
    correlated with the aggressive phenotype of the non-small cell lung cancer cell
    constitutional     --low  
    is associated with risk of Behçet disease (BD)
    constitutional     --over  
    expression of CCR1 and CCR2 is up-regulated in peripheral blood B cells upon EBV infection
    constitutional     --low  
    in narcolepsy
    constitutional     --over  
    in endometrial cells was significantly higher in women with adenomyosis compared to those without adenomyosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerlung 
    might be a new target for non-small cell lung cancer therapy
    allergy  
    potential target for alleviating T-cell accumulation during exacerbation of asthmatic disease
    osteoarticularboneostéoporosis
    target of new therapeutic strategies for the treatment of patients with bone destruction diseases and osteoporosis
    cancerdigestiveliver
    blockade of CCL15-CCR1 axis in hepatocellular carcinoma (HCC) could be an effective anticancer therapy
    immunologyinflammatory 
    CCR1 and its ligands may be a potential target for treating inflammatory diseases involving upregulation of cell adhesion molecules
    cancerdigestiveliver
    CCR1 is a potential therapeutic target for controlling metastasis in HCC patients with high SPP1
    cancerdigestiveliver
    may be a potential molecular target in hepatocellular carcinoma therapy
    miscelleaneouspain 
    at the inflammatory site, CCR1 antagonism may provide a dual benefit by restricting leukocyte trafficking and reducing pain
    ANIMAL & CELL MODELS
    CCR1-deficient mice have fewer and thinner trabecular bones and low mineral bone density in cancellous bones