Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PLIN3 contributors: mct - updated : 23-06-2010
HGNC name perilipin 3
HGNC id 16893
Location 19p13.3      Physical location : 4.838.345 - 4.867.780
Synonym name
  • mannose-6-phosphate receptor binding protein 1
  • cargo selection protein (mannose 6 phosphate receptor binding protein)
  • placental protein 17
  • cargo selection protein
  • MPR-BINDING PROTEIN, 47-KD
  • tail-interacting protein, 47 kD
  • Synonym symbol(s) PP17, TIP47, M6PRBP1, MGC11117, MGC2012, PP17B
    DNA
    TYPE functioning gene
    STRUCTURE 29.33 kb     8 Exon(s)
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 2342 - 433 - 2009 19638644
    8 - 2304 - 422 - 2009 19638644
    8 - 2345 - 434 - 2009 19638644
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue   
    Lymphoid/Immunelymph node    
    Skin/Tegumentskin   highly
    cell lineage
    cell lines
    fluid/secretion lymph
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to rattus M6prbp1 (74.60 pc)
    homolog to murine M6prbp1 (75.52 pc)
    Homologene
    FAMILY
  • perilipin family
  • CATEGORY transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    text
  • resides in a late endosome microdomain together with mannose 6-phosphate receptors (MPRs) and RAB9A
  • occurs in the cytosol and on endosomal membranes, and shuttles between these two compartment
  • basic FUNCTION
  • lipid droplet protein that regulate cellular neutral lipid stores
  • required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network
  • delivering lysosomal hydrolase from the Golgi to endosomes and then return to the Golgi complex
  • involved in lipid droplets
  • cytosolic protein that is essential for the transport of mannose 6-phosphate receptors (MPRs) from endosomes to the trans-Golgi
  • has apolipoprotein-like properties and reorganizes liposomes into small lipid discs
  • may act as a carrier protein for free fatty acids and in this way participates in conversion of macrophages into foam cells
  • can reorganize liposomes into small lipid discs, and it is recruited to lipid droplets
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule other,
  • can bind to mitochondria in oxidative stress, and inhibit mitochondria mediated cell death by protecting mitochondrial membrane integrity
  • protein
  • M6PR
  • IGF2R
  • interacting with RAB9A
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in cervical tumors, with correlation between the invasiveness and the amount in the cells and the sera
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS