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FLASH GENE
Symbol RAB43 contributors: mct - updated : 27-04-2012
HGNC name RAB43, member RAS oncogene family
HGNC id 19983
Location 3q21.3      Physical location : 128.806.417 - 128.840.619
Synonym name
  • ras-related protein Rab-41
  • ras-related protein Rab-43
  • Synonym symbol(s) RAB41, RAB11B
    DNA
    TYPE functioning gene
    STRUCTURE 34.58 kb     14 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 4232 - 212 - 2007 17684057
    4 - 4220 - 212 - 2007 17684057
    4 - 4210 - 212 - 2007 17684057
    4 - 4247 - 212 - 2007 17684057
    3 - 4484 - 108 - 2007 17684057
    3 - 4498 - 212 - 2007 17684057
    4 - 4592 - 155 - 2007 17684057
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY isy1-like splicing family
    CATEGORY signaling , transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • involved in intracellular transport
  • RAB1A and RAB43 are key Rabs required for the biogenesis and maintenance of a functional Golgi structure, and suggest that other Rabs acting at the Golgi complex are likely to be functionally redundant
  • RAB18 and RAB43, strongly indicated roles in ER-Golgi trafficking
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • redistributes the p150(Glued) subunit of DCTN1, consistent with a specific role in regulating association of pre-Golgi intermediates with microtubules
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS