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FLASH GENE
Symbol BRD9 contributors: mct/npt - updated : 16-12-2020
HGNC name bromodomain containing 9
HGNC id 25818
Location 5p15.33      Physical location : 863.850 - 892.939
Synonym name
  • rhabdomyosarcoma antigen MU-RMS-40.8
  • sarcoma antigen NY-SAR-29
  • Synonym symbol(s) FLJ13441, DKFZp434D0711, DKFZp686L0539, LAVS3040, PRO9856
    DNA
    TYPE functioning gene
    STRUCTURE 29.07 kb     16 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 2665 67 597 - 2019 31000698
    14 - 2526 60.6 544 - 2019 31000698
    16 - 2662 - 596 - 2019 31000698
    16 - 2725 - 617 - 2019 31000698
    17 - 2815 - 647 - 2019 31000698
    17 - 2788 - 638 - 2019 31000698
    16 - 2844 - 501 - 2019 31000698
    16 - 2731 - 619 - 2019 31000698
    16 - 2671 - 599 - 2019 31000698
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveintestinelarge intestinecolon  
    Respiratorylung    
    Urinarykidney    
    cell lineage
    cell lines Ewing's sarcoma
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • bromodomains
  • HOMOLOGY
    interspecies homolog to murine Brd7
    Homologene
    FAMILY
    CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • may be involved in protein-protein interactions
  • may play a role in assembly or activity of multi-component complexes involved in transcriptional activation
  • play a role in DNA repair and cell cycle regulation (Scotto 2008)
  • has an important role in maintaining the naive pluripotent state
  • BRD9 having functions within the naive pluripotency regulatory network by associating with a non-canonical GBAF complex, which is recruited to target sites via BD-dependent recognition of BRD4
  • BRD9 is an important mediator of mutant PIK3CA/KRAS-driven oncogenic transformation
  • role for BRD9 in homologous recombination (HR)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • BRD9 is part of the ESC pluripotency transcriptional regulatory network
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • acute myeloid leukemia (AML) cells require the BRD9 subunit of the SWI-SNF chromatin-remodeling complex to sustain MYC transcription, rapid cell proliferation and a block in differentiation
  • BRD9 interacts with BRD4 in a bromodomain-dependent fashion, which leads to the recruitment of GBAF complexes to chromatin, explaining the functional similarity between these epigenetic regulators
  • BRD9 and BRG1 cooperate to regulate a subset of genes in ESCs that are critical for ESC maintenance
  • BICRA and BICRAL each exclusively associate with BRD9, but not with SMARCB1 (PMID;
  • BRD9 binds enhancer regions in a cell type-specific manner, regulating cell type-related processes
  • BRD9-STAT5 axis as critical for leukemia maintenance
  • the bromodomain of BRD9 binds acetylated K515 on ATRX and facilitates ATRX interaction with RAD51, which is essential for HR
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification    
    in early stages of non-small cell lung cancer (Kang 2008)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    as a potential therapeutic target for leukemia
    cancer  
    potential therapeutic target to promote synthetic lethality and overcome chemoresistance
    cancer  
    BRD9 inhibitors may show utility in preventing epigenetically-defined drug resistance
    ANIMAL & CELL MODELS