basic FUNCTION
| may play a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus |
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plays a role in transcriptional coactivation |
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with GSK3, play a role in the complex network that regulates PTPRC alternative splicing |
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can trigger mRNA degradation in the nucleus |
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multi-functional protein involved in nuclear mRNA metabolism, in pre-mRNA splicing and, unexpectedly, in nuclear mRNA degradation |
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acts as a splicing activator and may participate in a step that is critical for pre-mRNA splicing in cells but not in the extract |
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role for RNA processing factor THRAP3 in the DNA damage response |
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could play indispensable roles in terminal differentiation of adipocytes by enhancing PPARG-mediated gene activation cooperatively with HELZ2 |
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BCLAF1 has functions distinct from THRAP3 in regulating the subcellular distribution of mRNAs in human cells |
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promotes CLOCK-ARNTL binding to target genes and links CLOCK-ARNTL to the transcriptional machinery at target-gene promoters |
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is itself clock-regulated, and its coactivator function creates a positive feedback loop nested within the core circadian negative feedback loop |
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RNA processing factors THRAP3 and BCLAF1 promote the DNA damage response through selective mRNA splicing and nuclear export |