Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | OSCAR | contributors: mct - updated : 04-04-2012 |
HGNC name | osteoclast associated, immunoglobulin-like receptor |
HGNC id | 29960 |
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Location | 19q13.42 Physical location : 54.597.934 - 54.604.148 |
Synonym name | |
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Synonym symbol(s) | PIGR3, MGC33613, PIgR-3 |
DNA |
TYPE | functioning gene |
STRUCTURE | 8.02 kb 6 Exon(s) |
10 Kb 5' upstream gene genomic sequence study |
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regulatory sequence | Promoter |
Binding site enhancer | |
text structure |
MAPPING | cloned | Y | linked | N | status | provisional |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type | widely |
expressed in | (based on citations) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
organ(s) |
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tissue |
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cells |
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cell lineage | in cells of the myeloid lineage |
cell lines
fluid/secretion
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at STAGE |
physiological period | pregnancy |
Text | placenta |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
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motifs/domains
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HOMOLOGY |
Homologene |
FAMILY | |
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CATEGORY | receptor |
SUBCELLULAR LOCALIZATION | extracellular |
plasma membrane | |
intracellular | |
intracellular,cytoplasm,organelle,membrane | |
intracellular,cytoplasm,organelle,endoplasmic reticulum | |
intracellular,cytoplasm,cytosolic,granule |
basic FUNCTION | |
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CELLULAR PROCESS |
PHYSIOLOGICAL PROCESS |
PATHWAY |
metabolism |
signaling |
a component |
INTERACTION |
DNA |
RNA |
small molecule |
protein | |
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cell & other |
REGULATION |
induced by | induced in monocytes of rheumatoid arthritis patients, facilitating their differentiation into osteoclasts and bone resorption |
repressed by | FKBP3 (both TREM2 and OSCAR were inhibited by FKBP3 in the late stage of osteoclast formation) |
PHYSICAL PROPERTIES
STRUCTURE
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motifs/domains
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HOMOLOGY |
Homologene |
FAMILY | leukocyte receptor complex (LRC) protein family |
CATEGORY | regulatory |
SUBCELLULAR LOCALIZATION | extracellular |
plasma membrane | |
intracellular | |
intracellular,cytoplasm,organelle,membrane | |
intracellular,cytoplasm,organelle,endoplasmic reticulum | |
intracellular,cytoplasm,cytosolic,granule |
basic FUNCTION | may be an important bone-specific regulator of osteoclast differentiation |
CELLULAR PROCESS |
PHYSIOLOGICAL PROCESS |
PATHWAY |
metabolism |
signaling |
a component |
INTERACTION |
DNA |
RNA |
small molecule |
protein |
cell & other |
REGULATION |
induced by | induced in monocytes of rheumatoid arthritis patients, facilitating their differentiation into osteoclasts and bone resorption |
repressed by | FKBP3 (both TREM2 and OSCAR were inhibited by FKBP3 in the late stage of osteoclast formation) |
ASSOCIATED DISORDERS |
corresponding disease(s) |
Susceptibility | to postmenopausal osteoporosis |
Variant & Polymorphism other | |
Candidate gene
Marker
| Therapy target
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ANIMAL & CELL MODELS |