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FLASH GENE
Symbol OSCAR contributors: mct - updated : 04-04-2012
HGNC name osteoclast associated, immunoglobulin-like receptor
HGNC id 29960
Location 19q13.42      Physical location : 54.597.934 - 54.604.148
Synonym name
  • osteoclast-associated receptor
  • osteoclast associated receptor OSCAR-S1
  • osteoclast associated receptor OSCAR-S2
  • polymeric immunoglobulin receptor 3
  • Synonym symbol(s) PIGR3, MGC33613, PIgR-3
    DNA
    TYPE functioning gene
    STRUCTURE 8.02 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site   enhancer
    text structure
  • two potential E-box elements for microphthalmia transcription factor (MITF) and three putative PU.1 sites, synergistically activating OSCAR gene expression
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 2073 - 286 - 2004 15155468
    - - 1910 - 274 - 2004 15155468
    6 - 1547 - 263 - 2004 15155468
  • OSCAR M1, or V4
  • 7 - 1559 - 267 - 2004 15155468
  • OSCAR M2, or V3
  • 5 - 1514 - 252 - 2004 15155468
  • OSCAR M3, or V5
  • 4 - 2028 - 271 - 2004 15155468
    5 - 2061 - 282 - 2004 15155468
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel     Homo sapiens
    Digestiveliver   highly
    Endocrinethyroid   highly
    Respiratorylung   highly
    Visualeyelacrimal gland   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte Homo sapiens
    Blood/Hematopoieticmyelocyte Homo sapiens
    Cardiovascularendothelial cell Homo sapiens
    Lymphoid/Immunedendritic cell
    Lymphoid/Immunemacrophage Homo sapiens
    Skeletonosteoblast Homo sapiens
    Skeletonosteoclast Homo sapiens
    cell lineage in cells of the myeloid lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two Ig-like domains
  • HOMOLOGY
    Homologene
    FAMILY
  • leukocyte receptor complex (LRC) protein family
  • Immunoglobulin family
  • CATEGORY receptor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,granule
    basic FUNCTION
  • may be an important bone-specific regulator of osteoclast differentiation
  • FcRgamma-associated receptor expressed by myeloid cells and involved in antigen presentation and activation of dendritic cells
  • IgG-like receptor, identified as an important osteoimmunological mediator
  • important costimulatory receptor for osteoclast differentiation through activation of NFATC1
  • may contribute to the pathogenesis and severity of osteoporosis and rheumatoid arthritis
  • regulator of osteoclast differentiation and dendritic cell maturation
  • may be involved in cell activation and inflammation during atherosclerosis
  • rotative stress has a significant effect on CA2, FAS, FASLG, OSCAR, and TRAP gene expression in osteoclasts
  • collagen-binding immune receptor with important roles in dendritic cell maturation and activation of inflammatory monocytes as well as in osteoclastogenesis
  • activating receptor expressed by human myeloid cells
  • promotes functional maturation of monocyte-derived dendritic cells
  • OSCAR can play a proinflammatory role in monocyte-derived cells and may contribute crucially on multiple levels to rheumatoid arthritis pathogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NFATC1 is a key transcription factor, playing a role in regulating expression of osteoclast-specific downstream target genes such as ACP5 and OSCAR
  • binds to specific motifs within fibrillar collagens in the ECM that become revealed on nonquiescent bone surfaces in which osteoclasts undergo maturation and terminal differentiation
  • OSCAR and TREM2 are essential receptors that pair with adaptor molecules Fc receptor common gamma chain (FCR1G) and TYROBP respectively to induce calcium signalling
  • putative binding motif for OSCAR within the SFTPD collagenous domain, and interaction is a potential therapeutic target in chronic inflammatory diseases of the lung as well as other diseases involving tissue accumulation of SFTPD, infiltration of inflammatory monocytes
  • OSCAR-collagen interaction stimulates TNFRSF11A-dependent osteoclastogenesis
  • cell & other
    REGULATION
    induced by induced in monocytes of rheumatoid arthritis patients, facilitating their differentiation into osteoclasts and bone resorption
    repressed by FKBP3 (both TREM2 and OSCAR were inhibited by FKBP3 in the late stage of osteoclast formation)
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY leukocyte receptor complex (LRC) protein family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,granule
    basic FUNCTION may be an important bone-specific regulator of osteoclast differentiation
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by induced in monocytes of rheumatoid arthritis patients, facilitating their differentiation into osteoclasts and bone resorption
    repressed by FKBP3 (both TREM2 and OSCAR were inhibited by FKBP3 in the late stage of osteoclast formation)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to postmenopausal osteoporosis
    Variant & Polymorphism other
  • genetic variations in OSCAR identify it as a potential underlying factor in postmenopausal osteoporosis
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS