basic FUNCTION
| may be involved in progesterone-induced progesterone receptors ubiquitination and degradation |
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represses progesterone receptors transactivation, inhibits the ability of PR to stimulate rapid MAPK activity, and impairs the effect of progesterone on breast cancer cell growth |
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acts as an adaptor protein to target IKK for dephosphorylation and inactivation by recruiting PP1 |
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key factor in endocrine resistance in breast cancer |
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modulates ESR1 protein stability through the ubiquitin-proteasome pathway |
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crucial determinant of resistance to endocrine therapies in breast cancer through affecting ESR1 protein stability |
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cell-cycle regulator that promotes spindle checkpoint inactivation and releases CDC20 from checkpoint inhibition |
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key regulator of mitosis progression, and its dysregulation might contribute to tumour development by causing chromosomal instability |
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CUEDC2 cooperates with SOCS3 to suppress the JAK/STAT signaling pathway |
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potential critical roles of CUEDC2 in the complex signal transduction network |