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FLASH GENE
Symbol CUEDC2 contributors: mct - updated : 05-10-2010
HGNC name CUE domain containing 2
HGNC id 28352
Location 10q24.32      Physical location : 104.183.001 - 104.192.423
Synonym name chromosome 10 open reading frame 66
Synonym symbol(s) MGC2491, C10orf66, bA18I14.5
DNA
TYPE functioning gene
STRUCTURE 9.43 kb     9 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 1203 32 287 - 2007 17347654
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a CUE domain
  • a ubiquitin-binding motif
  • HOMOLOGY
    interspecies ortholog to murine Cuedc2
    Homologene
    FAMILY
  • CUEDC2 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • may be involved in progesterone-induced progesterone receptors ubiquitination and degradation
  • represses progesterone receptors transactivation, inhibits the ability of PR to stimulate rapid MAPK activity, and impairs the effect of progesterone on breast cancer cell growth
  • acts as an adaptor protein to target IKK for dephosphorylation and inactivation by recruiting PP1
  • key factor in endocrine resistance in breast cancer
  • modulates ESR1 protein stability through the ubiquitin-proteasome pathway
  • crucial determinant of resistance to endocrine therapies in breast cancer through affecting ESR1 protein stability
  • cell-cycle regulator that promotes spindle checkpoint inactivation and releases CDC20 from checkpoint inhibition
  • key regulator of mitosis progression, and its dysregulation might contribute to tumour development by causing chromosomal instability
  • CUEDC2 cooperates with SOCS3 to suppress the JAK/STAT signaling pathway
  • potential critical roles of CUEDC2 in the complex signal transduction network
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with progesterone receptors and promotes progesterone-induced PR degradation by the ubiquitin-proteasome pathway
  • interacted with IKKalpha and IKKbeta and repressed activation of the transcription factor NF-kappaB by decreasing phosphorylation and activation of IKK
  • also interacted with PPP1R15A, a regulatory subunit of protein phosphatase 1 (PP1)
  • inhibits JAK1/STAT3 signaling through binding to SOCS3 (interaction between CUEDC2 and SOCS3 is required for the inhibitory effect of CUEDC2 on JAK1 and STAT3 activity)
  • impairs JAK1 and STAT3 phosphorylation and inhibits STAT3 transcriptional activation
  • enhances the interaction of SOCS3 and Elongin C, thus inhibiting SOCS3 degradation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    confers endocrine resistance in breast cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS