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FLASH GENE

Symbol

ENKUR

contributors: np/ - updated : 07-11-2005

HGNC name	enkurin, TRPC channel interacting protein
HGNC id	28388

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	10p12.1      Physical location : 25.270.916 - 25.305.030
Synonym name	enkurin
	chromosome 10 open reading frame 63
Synonym symbol(s)	MGC26778, C10orf63, enkurin, DKFZp781F21103

DNA

TYPE	functioning gene
STRUCTURE	34.11 kb     6 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_145010 6 - 3318 NP_659447 - 256 - -

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive male system testis

cell lineage
cell lines
fluid/secretion	sperm

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a C-terminal region, essential for channel interaction
	an IQ motif binding the Ca2+ sensor, calmodulin, in a Ca2+-dependent manner
	a proline-rich N-terminal region containing predicted ligand sequences for SH3 domain proteins

HOMOLOGY

Homologene

FAMILY

CATEGORY

adaptor

SUBCELLULAR LOCALIZATION

basic FUNCTION

may function to localize a Ca2+ sensitive signal transduction machinery in sperm to a Ca2+-permeable ion channel

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

interacting with TRPC1, TRPC2, TRPC5

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS