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FLASH GENE
Symbol FCRL3 contributors: mct/npt - updated : 18-05-2009
HGNC name Fc receptor-like 3
HGNC id 18506
Location 1q23.1      Physical location : 157.647.978 - 157.670.647
Synonym name
  • SH2 domain-containing phosphatase anchor protein 2
  • Fc receptor-like protein 3
  • immunoglobulin superfamily receptor translocation associated protein 3
  • Synonym symbol(s) SPAP2, FCRH3, IFGP3, IRTA3, SPAP2a, SPAP2b, SPAP2c, SPAP2d, SPAP2e
    DNA
    TYPE functioning gene
    STRUCTURE 22.67 kb     15 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 splicing 3019 - 735 - Xu, Davis (2001)
    - splicing 2514 - 639 - -
    - splicing 2817 - 740 - Xu
    - splicing 3033 - 189 - Xu
    - splicing 2704 - 199 - Xu
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node    
     spleen   highly
     tonsils   highly
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymhoid/Immunelymphocyte
    Lymphoid/Immunemacrophage
    Lymphoid/Immunenatural killer
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a hydrophobic signal peptide
  • six extracellular C2 type Ig-like domains
  • seven N-linked glycosylation sites
  • an uncharged transmembrane segment
  • a 140-amino acid cytoplasmic tail with 1 ITAM (immunoreceptor tyrosine-based activation motif)
  • one ITIM (immunoreceptor tyrosine-based inhibitory motif)
  • an ITAM-like region
  • HOMOLOGY
    interspecies homolog to murine Fcrl5
    Homologene
    FAMILY
  • immunoglobulin receptor superfamily
  • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    basic FUNCTION
  • receptor for the fc region of complexed immunoglobulins gamma
  • playing a role in immunity and autoimmune disorders
  • playing a role in regulating activation of normal B cells and possibly the development of neoplasia
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility rheumatoid arthritis (RA) and several autoimmunities
    Variant & Polymorphism SNP
  • SNP increasing the risk of rheumatoid arthritis and several autoimmunities
  • promoter polymorphism of FCRL3 (rs7528684) is associated with an increased risk of developing RA in Dutch Caucasians
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS