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FLASH GENE
Symbol HSD17B11 contributors: npt/ - updated : 11-03-2004
HGNC name hydroxysteroid (17-beta) dehydrogenase 11
HGNC id 22960
Location 4q22.1      Physical location : 88.257.690 - 88.312.455
Synonym name
  • 17-BETA-HSD11
  • 17-BETA-HSDXI
  • dehydrogenase/reductase (SDR family) member 8
  • 17-beta-hydroxysteroid dehydrogenase type XI
  • retinal short-chain dehydrogenase/reductase 2
  • CTCL tumor antigen HD-CL-03
  • short chain dehydrogenase/reductase family 16C, member 2
  • cutaneous T-cell lymphoma-associated antigen HD-CL-03
  • Synonym symbol(s) PAN1B, RETSDR2, DHRS8, 17-BETA-HSD11, 17-BETA-HSDXI, UNQ207/PRO233, SDR16C2
    EC.number 1.1.1.62
    DNA
    TYPE functioning gene
    STRUCTURE 54.76 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1892 33 300 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveliver   highly
    Endocrinepancreas   highly
    Reproductivefemale systemovary  highly
     male systemtestis   
    Respiratorylung   highly
    Skin/Tegumentskin appendagesskin glandsebaceous gland  
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularexocrine 
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivegranulosa cell
    ReproductiveLeydig cell
    reproductiveovary
    cell lineage
    cell lines steroidogenic cells
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a SDR motif
  • HOMOLOGY
    interspecies ortholog to murine Dhrs8
    Homologene
    FAMILY
  • short-chain dehydrogenases/reductases (SDR) family
  • 17-beta-HSD 3 subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • role in androgen metabolism during steroidogenesis, converts 5-alpha-androstane-3-alpha, 17-beta-diol to androsterone
  • oxidoreductase activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism hormone
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other down-regulated by cAMP
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS