basic FUNCTION
| may play a novel role in the regulatory of SMAD4 through phosphorylation |
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suppresses Notch signalling by interfering with formation of the Notch active transcriptional complex |
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suppresses Notch signalling by interfering with formation of the Notch active transcriptional complexconserved serine/threonine kinase that suppresses beta-catenin/T-cell factor (TCF) complex transcriptional activity through phosphorylation of TCF |
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its expression is altered during prostate cancer progression and is involved in regulation of AR signaling in these cells |
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induces apoptosis in glioma cells via activation of caspases |
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potentially serves as a conserved molecular link between core planar cell polarity factors and E-cadherin-CTNNB complexes, promoting cell motility |
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potential clock kinase |
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suppressor of tumor necrosis factor (TNF)-induced NFKB1 signaling by inhibiting the phosphorylation of IKBKB |
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NLK mediates aberrant erythropoiesis in Diamond Blackfan Anemia (DBA) |