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FLASH GENE
Symbol MX1 contributors: mct - updated : 14-10-2009
HGNC name myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
HGNC id 7532
Location 21q22.3      Physical location : 42.792.519 - 42.831.140
Synonym name
  • interferon-induced protein p78
  • interferon-regulated resistance GTP-binding protein MxA
  • myxovirus resistance protein 1
  • Synonym symbol(s) IFI78, MX, MxA, IFI-78K
    DNA
    TYPE functioning gene
    STRUCTURE 38.62 kb     17 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    Map see ETS2 , TFF1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 3409 - 662 - 2009 19297326
    17 - 2983 - 662 - 2009 19297326
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   highly
     thymus   highly
    Cardiovascularheart    
    Endocrinepancreas    
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a tripartite GTP-binding domain consisting of GxxxxGKS, DxxG and TKxD
  • HOMOLOGY
    interspecies ortholog to murine Mx2
    ortholog to rattus mx2
    intraspecies homolog to MX2
    Homologene
    FAMILY
  • dynamin family
  • family of large GTPases
  • CATEGORY immunity/defense , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • GTPase
  • induction of apoptosis
  • regulatory protein involved in Ca2+ signaling
  • showing activity against influenza virus and vesicular stomatitis virus (VSV) a rhabdovirus
  • recognizes the viral nucleocapsid protein and interferes with its role in viral genome replication
  • having certain characteristics of the stress proteins
  • inhibits tumor cell motility and invasion
  • MX1 and MX2 are intracellular proteins that are induced exclusively by type I IFNs
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • self-assemble into homo-oligomers in vitro
  • INTERACTION
    DNA
    RNA
    small molecule metal binding, nucleotide,
  • GTP
  • mg2+
  • protein
  • binding to elements of the cytoskeleton, such as actin and tubulins
  • interacts with the second ankyrin-like repeat domain of TRPC6 and interacted with TRPC1, -3, -4, -5, and -7 (regulated the activity of TRPC6 by a mechanism requiring GTP binding)
  • cell & other
    REGULATION
    induced by interferons (alpha and beta at least)
    by small molecules
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in end-stage dilated cardiomyopathy
    tumoral     --low  
    by hypermethylation in head and neck tumors
    constitutional     --other  
    in multiple sclerosis, MX1 and MX2 proteins are detectable in plaques suggesting endogenous synthesis of type I IFNs as part of the acute inflammatory process
    Susceptibility susceptibility factor for alopecia areata
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancermetastases 
    its expression can be induced by small molecules, potentially offering a new approach to the prevention and treatment of metastasis
    ANIMAL & CELL MODELS