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FLASH GENE
Symbol CDKN2AIP contributors: mct/pgu - updated : 21-04-2009
HGNC name CDKN2A interacting protein
HGNC id 24325
Location 4q35.1      Physical location : 184.365.788 - 184.369.049
Synonym name
  • collaborates/cooperates with ARF (alternate reading frame) protein
  • Collaborator of ARF
  • Synonym symbol(s) FLJ29936, CARF
    DNA
    TYPE functioning gene
    STRUCTURE 3.00 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 2391 - 580 - 2009 19001376
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus    
     intestinesmall intestine   
    Lymphoid/Immunethymus    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to rattus rgd1305302
    Homologene
    FAMILY
    CATEGORY RNA associated , transcription factor , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleolus
    text colocalizing with p14ARF
    basic FUNCTION
  • enhance ARF-dependent and -independent wild-type TP53 function
  • playing a role in senescence of primary cells and activating pathways for cell cycle control and tumor suppression
  • plays a dual role in regulating p53-mediated senescence and apoptosis, the two major tumor suppressor mechanisms
  • required for normal progression and completion of cell division and its absence causes mitotic catastrophe/apoptosisb
  • pleiotropic regulator with widespread effects
  • has a vital role in genome preservation and tumor suppression
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    component of the p14ARF-TP53-CDKN1A (p21) pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein p14ARF
    cell & other
    REGULATION
    repressed by degradation by MDM2
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    causes premature senescence of fibroblasts
    constitutional        
    causes aneuploidy and apoptosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    CDKN2AIP siRNA is an effective novel cancer therapeutic agent
    ANIMAL & CELL MODELS