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FLASH GENE
Symbol ARL5B contributors: mct - updated : 06-02-2019
HGNC name ADP-ribosylation factor-like 5B
HGNC id 23052
Location 10p13      Physical location : 18.948.312 - 18.966.940
Synonym name ADP-ribosylation factor-like 8
Synonym symbol(s) ARL8
DNA
TYPE functioning gene
STRUCTURE 18.00 kb     6 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Endocrinepancreas   highly
Reproductivefemale systembreastmammary gland  
 female systemuterus   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text cartilage
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Arl8
intraspecies homolog to ARL5
Homologene
FAMILY
  • small GTPase superfamily
  • ADP-ribosylation factors (ARF) family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • involved in regulating cell growth and signal transduction, organization of the cytoskeleton and regulating membrane trafficking along the exocytic and endocytic pathways
  • in uninfected cells both ARL5B and PLEKHM2 are required for lysosomes to distribute away from the microtubule-organizing center
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • GTP
  • protein
  • ARL5B-GTP binds to the soluble protein PLEKHM2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS