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FLASH GENE
Symbol NLRP13 contributors: mct - updated : 09-01-2007
HGNC name NLR family, pyrin domain containing 13
HGNC id 22937
Location 19q13.43      Physical location : 56.407.312 - 56.443.702
Synonym name
  • NACHT, leucine rich repeat and PYD containing 13
  • nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 13
  • caterpiller (CARD, Transcription Enhancer, R (purine)-binding, Pyrin, Lots of Leucine Repeats)19.7
  • Synonym symbol(s) NOD14, NALP13, CLR19.7, PAN13
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text component of a cluster of PYPAF genes
    STRUCTURE 36.00 kb     11 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunethymus    
    Reproductivefemale systemplacenta   
    Respiratorylung    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a DAPIN domain
  • a NACHT domain
  • 9 LRR(leucine-rich) repeats
  • HOMOLOGY
    Homologene
    FAMILY NALP family, caterpiller family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • may be involved in inflammation
  • may be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspase
  • implicated in the activation of caspase-1 by the Toll-like receptors (TLRs) during the cells response to microbial infection (Tschopp 2003)
  • play important roles in both mammalian innate immune system and reproductive system (Tian 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS inflammation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP binding
    protein interacts with CHUK, IKBKB and IKBKG, as well as with full-length PYCARD and with the dapin domain of NAPl1, but not the full-length protein
    cell & other
    REGULATION
    induced by interferons and lipopolysaccharide
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS